Gap junctions and the connexin protein family
نویسندگان
چکیده
منابع مشابه
Gap junctions and the connexin protein family.
Gap junctions (Gj) form conduits between adjacent cells that are composed of connexin (Cx) protein subunits and allow direct intercellular communication. To date, the connexin gene family comprises 20 members in the mouse and 21 members in the human genome, 19 of which can be grouped as sequence-orthologous pairs. The structure of connexin genes is relatively simple. An untranslated exon 1 is s...
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Institute for Cardiovascular & Metabolic Research, School of Biological Sciences, University of Reading, Reading, United Kingdom; Dept of Physiology, University of Arizona, Tucson, AZ; Dept of Cell Physiology & Pharmacology, University of Leicester, Leicester; Centre for Advanced Microscopy, University of Reading, Reading; Cardiovascular Biology Research, Faculty of Health and Medical Sciences,...
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BACKGROUND Connexins are a widespread family of membrane proteins that assemble into hexameric hemichannels, also known as connexons. Connexons regulate membrane permeability in individual cells or couple between adjacent cells to form gap junctions and thereby provide a pathway for regulated intercellular communication. We have examined the role of connexins in platelets, blood cells that circ...
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Gap junctions form the cell-to-cell pathways for propagation of the precisely orchestrated patterns of current flow that govern the regular rhythm of the healthy heart. As in most tissues and organs, multiple connexin types are expressed in the heart: connexin43 (Cx43), Cx40 and Cx45 are found in distinctive combinations and relative quantities in different, functionally-specialized subsets of ...
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The gap junction is a specialized contact between adjacent cells in a wide variety of tissues (1, 2) which is thought to mediate electrotonic coupling (3) . This junction is characterized by a hexagonal lattice of subunits which may be seen in lanthanum-impregnated, negative-stained, and freezefractured preparations (1) . A method for isolation of morphologically intact gap junctions from mouse...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2004
ISSN: 0008-6363
DOI: 10.1016/j.cardiores.2003.11.013